September 19, 2020

CSUN professor receives $1.4 million grant to study human gut

A Cal State Northridge microbial ecologist has received $1.4 million from the National Institutes of Health to help unravel mysteries involving the distinct bacterial community called the human gut microbiome, the university announced Tuesday, Sept. 15.

The four-year grant supports Dr. Gilberto Flores’ research in understanding how one particular bacterium, Akkermansia muciniphila — seen by many health food manufacturers as a potential “good” bacteria to add to their products — promotes health in its human hosts.

“The gut microbiome is an emerging field in the biomedical sciences,” Flores said. “What I am doing is really looking at our large intestine and the microbes that live in there, and trying to understand how they contribute to various aspects of our physiology.”

Flores said scientists have understood for years that the microbes in the large intestine help digest fibers from foodstuffs to produce energy, a process called fermentation.

“We’ve known they’ve been there for a very long time and usually think of them in terms of their fermentation ability,” he said. “As it turns out, they are doing a lot more than just fermenting fibers. They are contributing to a number of diseases, both positively and negatively. Basically, the microbes are communicating with our immune system, and even our brains, as it turns out.

“The gut is a very active area,” he said. “In order to maintain a healthy relationship with those microbes, we need to understand their biology and how they function.”

To do that, Flores said he takes a reductionist’s approach.

“Let’s understand the parts so we can understand the whole,” he said.

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Akkermansia muciniphila stands out because it sustains itself by consuming mucin, the main component of the mucus our bodies produce to, among other things, protect our cells. As Akkermansia consume mucin, they help signal our bodies to produce more, thus helping to maintain this protective barrier.

Flores’ lab is studying how Akkermansia interacts with the host and other organisms in the gut. Akkermansia is largely thought of as a keystone species, a species on which other species in an ecosystem — in this instance, the human gut — largely depend. If a keystone species was removed or its abundance was significantly altered, the ecosystem could be impacted dramatically.

Flores noted that Akkermansia play a role in every stage of human development, from helping infants digest breastmilk and other nutrients to helping adults regulate blood glucose levels. Given that role, Flores said health food manufacturers are keen to add the bacteria to their probiotic products.

Before that happens, Flores said, “we need to understand exactly the role Akkermansia play in (the) gut.”

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Source:: Los Angeles Daily News


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